Assessment of serum trace elements, lipid profile and proteins in hyperprolactinaemic female patients at a tertiary hospital in Abeokuta Évaluation des oligo-éléments sériques, du profil lipidique et des protéines chez des patientes hyperprolactinémiques dans un hôpital tertiaire d'Abeokuta
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Abstract
ENGLISH
Background: Hyperprolactinemia is a frequent endocrine syndrome with varied prevalence rates among infertile women and women with other gyneacological problems. Report has also shown that prolactin exerts a wide variety of actions on metabolic profile.
Objective: To determine the serum levels of Trace Elements, Lipid Profile and Proteins in hyperprolactinaemic female patients.
Methods: A total of 100 female participants were recruited, comprising 60 hyperprolactinaemic patients and 40 healthy controls. Ethical approval was obtained from the institutional review board, and informed consent was secured from all participants. Prolactin was estimated using Chemiluminescent Microparticle Immunoassay (CMIA) and trace elements were analysed using the Flame Atomic Absorption Spectrophotometer. Lipid profile and proteins were analysed using standard methods.
Results: Trace elements showed no significant difference in cases but their mean values were decreased. Cu was slightly elevated in cases. Significant (p<0.05) decrease and increase occurred in HDL and TG respectively in cases but there were no significant difference in TCHOL and LDL in cases. Albumin level was significantly (p<0.05) higher in cases but there were no significant difference (p>0.05) in total protein and globulin levels.
Conclusion: This study highlights significant metabolic alterations in hyperprolactinaemic female patients, particularly in, lipid profile, and albumin levels. These findings underscore the need for nutritional and therapeutic interventions to mitigate the metabolic impact of hyperprolactinaemia. On the levels of proteins hyperprolactinaemia caused albumin level to be significantly (p<0.05) increased while globulin and total protein levels were only slightly elevated in cases.
FRENCH
Contexte: L'hyperprolactinémie est un syndrome endocrinien fréquent dont la prévalence varie chez les femmes infertiles et celles présentant d'autres problèmes gynécologiques. Une étude a également montré que la prolactine exerce une grande variété d'actions sur le profil métabolique.
Objectif: Déterminer les taux sériques d'oligo-éléments, le profil lipidique et les protéines chez les patientes hyperprolactinémiques.
Méthodes: Au total, 100 participantes ont été recrutées, dont 60 patientes hyperprolactinémiques et 40 témoins sains. L'approbation éthique a été obtenue auprès du comité d'éthique institutionnel et le consentement éclairé de toutes les participantes. La prolactine a été estimée par dosage immunologique par microparticules chimioluminescentes (CMIA) et les oligo-éléments ont été analysés par spectrophotomètre d'absorption atomique à flamme. Le profil lipidique et les protéines ont été analysés selon des méthodes standard.
Résultats: Les oligo-éléments n'ont pas montré de différence significative entre les cas, mais leurs valeurs moyennes ont diminué. Le taux de Cu était légèrement élevé dans les cas. Une diminution et une augmentation significatives (p<0,05) des HDL et des TG ont été observées respectivement dans les cas, mais aucune différence significative n'a été observée entre les TCHOL et les LDL. Le taux d'albumine était significativement plus élevé (p<0,05) dans les cas, mais aucune différence significative n'a été observée (p>0,05) dans les taux de protéines totales et de globulines.
Conclusion: Cette étude met en évidence des altérations métaboliques significatives chez les patientes hyperprolactinémiques, notamment au niveau du profil lipidique et des taux d'albumine. Ces résultats soulignent la nécessité d'interventions nutritionnelles et thérapeutiques pour atténuer l'impact métabolique de l'hyperprolactinémie . En ce qui concerne les taux de protéines, l'hyperprolactinémie a entraîné une augmentation significative (p<0,05) du taux d'albumine, tandis que les taux de globuline et de protéines totales n'étaient que légèrement élevés dans certains cas.
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